15 October 2008

Every years people who get diagnosed obesity increasing more and more. Diet and regular physical activity necessary needed to lose weight and maintain weight loss over the long term. But for some people may need additional treatment. As with other chronic conditions, such as diabetes or high blood pressure, the use of prescription medications may be appropriate for some people who are overweight or obese.

Prescription weight-loss medications should be used only by patients who are at increased medical risk because of their weight. In addition, patients should have previously tried to lose weight through diet and physical activity.

Prescription weight-loss drugs requisite :
  • A body mass index (BMI) of 30 and above.
  • A BMI of 27 and above with an obesity-related condition, such as high blood pressure, type 2 diabetes, or dyslipidemia (abnormal amounts of fat in the blood).
Prescribed Medications That Promote Weight Loss
Generic NameFDA Approval for Weight LossDrug TypeSide Effects
SibutramineYes; long term (up to 1 year) for adultsAppetite SuppressantIncreased blood pressure and heart rate
PhentermineYes; short term (up to 12 weeks) for adultsAppetite SuppressantIncreased blood pressure and heart rate, sleeplessness, nervousness
DiethylpropionYes; short term (up to 12 weeks) for adultsAppetite SuppressantDizziness, headache, sleeplessness, nervousness
PhendimetrazineYes; short term (up to 12 weeks) for adultsAppetite SuppressantSleeplessness, nervousness
OrlistatYes; long term (up to 1 year) for adults and children age 12 and olderLipase InhibitorGastrointestinal issues (cramping, diarrhea, oily spotting)
BupropionNoDepression TreatmentDry mouth, insomnia
TopiramateNoSeizure TreatmentNumbness of skin, change in taste
ZonisamideNoSeizure TreatmentDrowsiness, dry mouth, dizziness, headache, nausea
MetforminNoDiabetes TreatmentWeakness, dizziness, metallic taste, nausea

Food and Drug Administration-Approved Prescription Weight-loss Medications

Most weight loss medications for weight loss that approved by Food Drug Administration (FDA) used for short-term use (a few weeks), but doctors may prescribe them for longer periods of time. Sibutramine and orlistat are the only weight-loss medications approved for longer-term use in patients who are significantly obese. Their safety and effectiveness have not been established for use beyond 2 years.

Appetite Suppressants. Appetite-suppressant medications work by decrease appetite or increasing the feeling of being full. These medications make you feel less hungry by increasing one or more brain chemicals that affect mood and appetite. Phentermine and sibutramine are the most commonly prescribed appetite-suppressants. Amphetamines are a type of appetite suppressant but not recommended for use in the treatment of obesity coz strong potential for abuse and dependence.

Lipase Inhibitors. Works by reduce the body’s ability to absorb dietary fat by about one-third and blocking the enzyme lipase, which is responsible for breaking down dietary fat. When fat is not broken down, the body cannot absorb it, so it is eliminated and fewer calories are taken in. Orlistat was approved for Over-The-Counter in 2007 for min 18 years old adult. The brand is Alli.

Drugs to treat depression. Some antidepressant medications has ability as appetite-suppressant medications. Studies of these medications have generally found that patients lose modest amounts of weight for up to 6 months, but that patients tend to regain weight while they are still on the drug. One exception is bupropion.

Drugs to treat seizures. Topiramate and zonisamide useful in treating obesity is being studied.

Drugs to treat diabetes. The diabetes medication metformin may promote small amounts of weight loss in people with obesity and type 2 diabetes. This drug reduces the feel of hunger and food intake in people taking the drug.

Drug combinations. Fenfluramine and Phentermine (known as “fen/phen”) had been withdrawal from market after some patients experienced serious heart and lung disorders. Little. Until more information on their safety or effectiveness is available, using combinations of medications for weight loss is not recommended, except as part of a research study.


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